Doctors

Dr. Prasanth Ariyannur


Designation :
Lab-in-charge
Department :
Molecular Oncology
Email :
prasanthas@aims.amrita.edu
Qualification :
MBBS, MS (Cellular & Molecular Biology)

Dr. Prasanth Ariyannur completed his MBBS in 2002 from Government Medical College, Trivandrum Kerala. After his MBBS, he started his human biology and life science research career as a research fellow at Rajiv Gandhi Center for Biotechnology under Dr. R. V. Omkumar. There he got training in mass spectrometry and proteomic analysis. Soon he went to the National Institute of Health at Bethesda Maryland USA for a Masters Program in Clinical Cellular and Molecular Biology in 2004. Then, he worked in neurobiology lab under at National Institute of Mental Health and subsequently at the Walter Reed Army Medical Institute/ Uniformed Services University of Health Sciences at Bethesda, Maryland USA, where he worked mostly in neurobiology under Dr. Aryan Namboodiri. During the twelve years of his work, he made significant contribution to neurobiology field, including the characterization and identification of Aspartate N-acetyltransferase enzyme from mammalian brain. Subsequently cloned, expressed the gene (NAT8L) and made transgenic knockout animal model and studied the behavioral and biochemical characteristic of gene knock out model. From the identification NAT8L he also studied the role of NAA in methamphetamine addiction and nucleus accumbens and other dopaminergic centers of the brian. Other significant projects included the characterization and central nervous location of Acetyl CoA short chain fatty acid synthetase type 2 (Acss2) and type 1 isoenzymes in mammalian brain. Studied the role of short chain fatty acid acetyl CoA in neuroenergetics and the role of N-acetylaspartate (NAA) in “mini citric acid cycle” and association of that in ATP generation in traumatic brain injury model.

Dr. Prasanth brought in a confluence of expertise in clinical as well as basic biochemical knowledge for high demands molecular biology techniques tailor made for somatic mutation analysis and its clinical interpretation in the field of molecular oncology. He initiated many newer and custom made sensitive tests as diagnostic tests to bring quality as well as affordability. As a team effort, with the onco-pathologists, oncologists, professional commercial laboratories, he has been introducing many tests essential for the diagnosis, management and therapeutics of cancer disorders.

Publications

  • Wen, J, Ariyannur PS, Riberio R, Tanaka M, Moffet J, Batool K, Namboodiri A. Comparative effects of N-acetylserotonin and melatonin in the EAE model of multiple sclerosis J. Neuroimmune pharmacology 2016 Dec;11(4):763-773. PMID: 27562847  
  • Vikkath N, Valiyaveedan S, Nampoothiri S, Radhakrishnan N, Pillai GS, Nair V, Pooleri GK, Mathew G, Menon KN, Ariyannur PS, Pillai AB. Familial Cancer 2015 Dec;14(4):585-94 DOI 10.1007/s10689-015-9806-z PMID: 25952756
  • Moffett JR, Arun P, Ariyannur PS, Namboodiri MA. Frontiers in Neuroenergetics. Invited Review. 2013 Editor. Cole JT. Dec;5(11)1-19. PMID: 24421768
  • Ariyannur PS, Arun P, Barry ES, Andrews-Shigaki B, Bosomtwi A, Tang H, Selwyn R, Moffett JR, Namboodiri AM. J. Neurosci. Res. 2013 July;91(7)934-942. doi: 10.1002/jnr.23234. PubMed PMID: 23633398.
  • Sharma P, Su YA, Barry ES, Grunberg NE, Ariyannur PS, Lei Z. Int J Crit Illn Inj Sci. 2012 Sep;2(3):172-9. doi:  10.4103/2229-5151.100931.
  • Moffett JR, Arun P, Ariyannur PS, Garbern JY, Jacobowitz DM, Namboodiri AM. Glia. 2011 Oct;59(10):1414-34. PubMed PMID: 21598311
  • Ariyannur PS, Moffett JR, Madhavarao CN, Arun P, Vishnu N, Jacobowitz DM, Hallows WC, Denu JM, Namboodiri AMA. J. Comp. Neurol. 2010 Aug 1;518(15):2952-77. PubMed PMID:20533355
  • Ariyannur PS, Moffett JR, Manickam P, Patabiraman N, Arun P, Nitta A, Nabeshima T, Madhavarao CN, Namboodiri AMA. Brain Res 2010 Jun 4;1335:1-13. PubMed PMID:20385109.
  • Arun P, Madhavarao CN, Moffett JR, Hamilton K, Grunberg NE, Ariyannur PS, Gahl WA, Anikster Y, Mog S, Hallows WC, Denu JM, Namboodiri AMA. J Inherit Metab Dis. 2010 Jun;33(3):195-210. PubMed PMID:20464498. 
  • Arun P, Ariyannur PS, Moffett JR, Xing G, Hamilton K, Grunberg NE, Ives JA, Namboodiri AMA. J Neurotrauma. 2010 Jan;27(1):293-8. PubMed PMID:19803785.
  • Ariyannur PS, Madhavarao CN, Namboodiri AM. Brain Res 2008; 1227: 34-41. PubMed PMID:18621030.
  • Namboodiri AM, Peethambaran A, Mathew R, Sambhu PA, Hershfield JR, Moffett JR, Madhavarao CN.  Mol Cell Endocrinol 2006; 252: 216-23. PubMed PMID: 16647192.

Book Chapters

  • John R. Moffett, Prasanth S. Ariyannur, Peethambaran Arun, Aryan M. A. Namboodiri (2014). “N-acetylaspartate and N-acetylaspartylglutamate in CNS Health and Disease” In “Magnetic Resonance Spectroscopy for Neuroscientists and Clinicians”, Charlotte Stagg and Douglas L. Rothman [eds.] Chapter 2.1 Elsevier
  • John R. Moffett, John A. Ives, Peethambaran Arun, Prasanth S. Ariyannur, Guoqiang Xing, Kristen Hamilton, Neil E Grunberg, and Aryan M. A. Namboodiri (2010).  “The Roles of Acetate and Acetyl-Coenzyme A in Traumatic Brain Injury” In “Traumatic Brain Injury: Mechanisms and Effects of a Neuropsychiatric Spectrum Disorder”. New York: Nova Press”, Giordano J., Waters P., [eds.] NY, Nova.

Non-peer reviewed Journal Publications 

  • Andrews-Shigaki, B., Namboodiri, A. M., Bosomtwi, A., Ariyannur, P., Moffett, J., Mao, X., Shungu, D., Selwyn, R., and Tang, H. Analysis of NAA in gene NAT8l knock out mice using proton Magnetic Resonance Spectroscopy. Cortex 37, 0.0142 Conference Proceedings
  • Schooley JF, Ariyannur PS, Bunger R, Namboodiri AMA, Flagg TP. Pharmacological Evidence Suggests Acetate and Pyruvate Modulate Myocyte Systolic and Diastolic Function by Effects on Mitochondrial Ca2+ Handling. Biophysical J, 31 January 2012:102(3), pp. 138a. Conference Proceedings
  • Ariyannur, P. S., Riberio, R., Kirmani, B. F., Moffett, J. R., Namboodiri, A., and Zhang, Y. (2011) Tryptophan Metabolites as Immune Regulators: Studies on Effectiveness in Experimental Autoimmune Encephalomyelitis. In NEUROLOGY Vol. 76 pp. A84-A84, LIPPINCOTT WILLIAMS & WILKINS 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
  • Sambhu PA, Madhavarao CN, Namboodiri A. Characterization of aspartate n-acetyltransferase from bovine brain, 35th Society for Neuroscience annual meeting neurobiology of lipids sessions. Neurobiol. Lipids, 2005 October 31:4(3). Abstract

Reviewer:

Journal of Neuroscience Letters
Brain Research

Professional Memberships:

Society for Neuroscience, SFN
American Association for the Advancement of Science, AAAS
Molecular and Cellular Cognition Society
Association of Clinical Biochemists, India

Research Interests:

  • Genotypic and phenotypic correlative studies on phakomatoses disorders such as Neurofibromatosis, type 1 and 2 and von Hippel Lindau syndrome
  • Role of hyaluronan in tumor microenvironment of syndromic and sporadic schwannomas and meningioma
  • Role of Fibronectin, VHL proteins in the tumor microenvironment of hemangioblastioma
  • Somatic mutation detection efficiency using different PCR methods
  • Genotypic and phenotypic correlation of syndromic colo-rectal cancer with DNA mismatch repair gene mutations, micro-satellite instability analysis, MLH1 hypermethylation and RAS/RAF mutations.
  • Role of immune cell infiltration and pathogenicity of hereditary and sporadic colo-rectal cancers
  • Role of short chain fatty acids in tumorogenic role in colo-rectal cancers.
  • Somatic genotypic and phenotypic correlation of BRCA gene mutations in breast cancers.

International Researcher Credentials

  • Scopus Author IDs:14018389800 / 24477357400
  • ORCHID ID: orcid.org/0000-0003-0888-8094
  • Researcher ID: C-1280-2008
  • Loop Profile ID: 113499
  • Google Scholar ID: Prasanth Ariyannur
  • LinkedIn profile: ariyannur